Möbitz, Henrik : rechercher sur Z-Library

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1

Members of the genus Arthrobacter grow anaerobically using nitrate ammonification and fermentative processes: anaerobic adaptation of aerobic bacteria abundant in soil

Martin Eschbach, Henrik Möbitz, Alexandra Rompf, Dieter Jahn

Journal:

FEMS Microbiology Letters

Année:

2003

Langue:

english

Fichier:

PDF, 179 KB

english, 2003

2

The ABC of protein kinase conformations

Möbitz, Henrik

Journal:

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics

Année:

2015

Langue:

english

Fichier:

PDF, 2.77 MB

english, 2015

3

In vivo and in vitro SAR of tetracyclic MAPKAP-K2 (MK2) inhibitors. Part II

Laszlo Revesz, Achim Schlapbach, Reiner Aichholz, Janet Dawson, Roland Feifel, Stuart Hawtin, Amanda Littlewood-Evans, Guido Koch, Markus Kroemer, Henrik Möbitz, Clemens Scheufler, Juraj Velcicky, Chr

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2010

Langue:

english

Fichier:

PDF, 888 KB

english, 2010

4

In vivo and in vitro SAR of tetracyclic MAPKAP-K2 (MK2) inhibitors. Part I

Laszlo Revesz, Achim Schlapbach, Reiner Aichholz, Roland Feifel, Stuart Hawtin, Richard Heng, Peter Hiestand, Wolfgang Jahnke, Guido Koch, Markus Kroemer, Henrik Möbitz, Clemens Scheufler, Juraj Velci

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2010

Langue:

english

Fichier:

PDF, 456 KB

english, 2010

5

Structure based design, synthesis and SAR of cyclic hydroxyethylamine (HEA) BACE-1 inhibitors

Heinrich Rueeger, Jean-Michel Rondeau, Clive McCarthy, Henrik Möbitz, Marina Tintelnot-Blomley, Ulf Neumann, Sandrine Desrayaud

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2011

Langue:

english

Fichier:

PDF, 776 KB

english, 2011

6

Discovery of Cyclic Sulfone Hydroxyethylamines as Potent and Selective β-Site APP-Cleaving Enzyme 1 (BACE1) Inhibitors: Structure-Based Design and in Vivo Reduction of Amyloid β-Peptides

Staufenbiel, Matthias, Desrayaud, Sandrine, Neumann, Ulf, Rueeger, Heinrich, Lueoend, Rainer, Rogel, Olivier, Rondeau, Jean-Michel, Möbitz, Henrik, Machauer, Rainer, Jacobson, Laura

Journal:

Journal of Medicinal Chemistry

Année:

2012

Langue:

english

Fichier:

PDF, 3.33 MB

english, 2012

7

Structural biology contributions to tyrosine kinase drug discovery

Sandra W Cowan-Jacob, Henrik Möbitz, Doriano Fabbro

Journal:

Current Opinion in Cell Biology

Année:

2009

Langue:

english

Fichier:

PDF, 1.72 MB

english, 2009

8

A Birch-like Mechanism in Enzymatic Benzoyl-CoA Reduction: A Kinetic Study of Substrate Analogues Combined with an ab Initio Model †

Möbitz, Henrik, Boll, Matthias

Journal:

Année:

2002

Langue:

english

Fichier:

PDF, 179 KB

english, 2002

9

Multiple Substrate Binding States and Chiral Recognition in Cofactor-independent Glutamate Racemase: A Molecular Dynamics Study †

Möbitz, Henrik, Bruice, Thomas C.

Journal:

Année:

2004

Langue:

english

Fichier:

PDF, 713 KB

english, 2004

10

Discovery of cyclic sulfoxide hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors: Structure based design and in vivo reduction of amyloid β-peptides

Rueeger, Heinrich, Lueoend, Rainer, Machauer, Rainer, Veenstra, Siem Jacob, Jacobson, Laura Helen, Staufenbiel, Matthias, Desrayaud, Sandrine, Rondeau, Jean-Michel, Möbitz, Henrik, Neumann, Ulf

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2013

Langue:

english

Fichier:

PDF, 1.90 MB

english, 2013

11

Substrate Binding and Reduction of Benzoyl-CoA Reductase: Evidence for Nucleotide-Dependent Conformational Changes †

Möbitz, Henrik, Friedrich, Thorsten, Boll, Matthias

Journal:

Année:

2004

Langue:

english

Fichier:

PDF, 138 KB

english, 2004

12

Type II Inhibitors Targeting CDK2

Alexander, Leila T., Möbitz, Henrik, Drueckes, Peter, Savitsky, Pavel, Fedorov, Oleg, Elkins, Jonathan M., Deane, Charlotte M., Cowan-Jacob, Sandra W., Knapp, Stefan

Journal:

ACS Chemical Biology

Année:

2015

Langue:

english

Fichier:

PDF, 1.33 MB

english, 2015

13

The Crystal Structure of Cancer Osaka Thyroid Kinase Reveals an Unexpected Kinase Domain Fold

Gutmann, Sascha, Hinniger, Alexandra, Fendrich, Gabriele, Drückes, Peter, Antz, Sylvie, Mattes, Henri, Möbitz, Henrik, Ofner, Silvio, Schmiedeberg, Niko, Stojanovic, Aleksandar, Rieffel, Sebastien, St

Journal:

Journal of Biological Chemistry

Année:

2015

Langue:

english

Fichier:

PDF, 2.51 MB

english, 2015

14

Discovery of Novel Dot1L Inhibitors through a Structure-Based Fragmentation Approach

Chen, Chao, Zhu, Hugh, Stauffer, Frédéric, Caravatti, Giorgio, Vollmer, Susanne, Machauer, Rainer, Holzer, Philipp, Möbitz, Henrik, Scheufler, Clemens, Klumpp, Martin, Tiedt, Ralph, Beyer, Kim S., Cal

Journal:

ACS Medicinal Chemistry Letters

Année:

2016

Langue:

english

Fichier:

PDF, 1014 KB

english, 2016

15

Optimization of a Fragment-Based Screening Hit toward Potent DOT1L Inhibitors Interacting in an Induced Binding Pocket

Scheufler, Clemens, Möbitz, Henrik, Gaul, Christoph, Ragot, Christian, Be, Céline, Fernández, César, Beyer, Kim S., Tiedt, Ralph, Stauffer, Frédéric

Journal:

ACS Medicinal Chemistry Letters

Année:

2016

Langue:

english

Fichier:

PDF, 2.36 MB

english, 2016

16

Discovery of Imidazoquinolines as a Novel Class of Potent, Selective, and in Vivo Efficacious Cancer Osaka Thyroid (COT) Kinase Inhibitors

Glatthar, Ralf, Stojanovic, Aleksandar, Troxler, Thomas, Mattes, Henri, Möbitz, Henrik, Beerli, Rene, Blanz, Joachim, Gassmann, Ernst, Drückes, Peter, Fendrich, Gabriele, Gutmann, Sascha, Martiny-Baro

Journal:

Journal of Medicinal Chemistry

Année:

2016

Langue:

english

Fichier:

PDF, 1.27 MB

english, 2016

17

Discovery of Potent, Selective, and Structurally Novel Dot1L Inhibitors by a Fragment Linking Approach

Möbitz, Henrik, Machauer, Rainer, Holzer, Philipp, Vaupel, Andrea, Stauffer, Frédéric, Ragot, Christian, Caravatti, Giorgio, Scheufler, Clemens, Fernandez, Cesar, Hommel, Ulrich, Tiedt, Ralph, Beyer,

Journal:

ACS Medicinal Chemistry Letters

Année:

2017

Langue:

english

Fichier:

PDF, 943 KB

english, 2017

18

New Potent DOT1L Inhibitors for in Vivo Evaluation in Mouse

Stauffer, Frédéric, Weiss, Andreas, Scheufler, Clemens, Möbitz, Henrik, Ragot, Christian, Beyer, Kim S., Calkins, Keith, Guthy, Daniel, Kiffe, Michael, Van Eerdenbrugh, Bernard, Tiedt, Ralph, Gaul, Ch

Journal:

ACS Medicinal Chemistry Letters

Année:

2019

Fichier:

PDF, 2.08 MB

2019